5TY2

Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin

Summary for 5TY2

Entry DOI	10.2210/pdb5ty2/pdb
Descriptor	Penicillin-binding protein 4, (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ... (6 entities in total)
Functional Keywords	hydrolase, antibiotic, hydrolase - antibiotic complex, hydrolase / antibiotic
Biological source	Staphylococcus aureus (strain COL)
Total number of polymer chains	2
Total formula weight	81595.31
Authors	Alexander, J.A.N.,Strynadka, N.C.J. (deposition date: 2016-11-18, release date: 2018-06-13, Last modification date: 2023-10-04)
Primary citation	Alexander, J.A.N.,Chatterjee, S.S.,Hamilton, S.M.,Eltis, L.D.,Chambers, H.F.,Strynadka, N.C.J. Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus. J. Biol. Chem., 2018 Cited by PubMed: 30366985 DOI: 10.1074/jbc.RA118.004952 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation