5TXY

Identification of a New Zinc Binding Chemotype of by Fragment Screening on human carbonic anhydrase

Summary for 5TXY

Entry DOI	10.2210/pdb5txy/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, FORMIC ACID, ... (5 entities in total)
Functional Keywords	human carbonic anhydrase, zinc binding chemotype, crystal, crystallization, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29577.65
Authors	Ren, B.,Peat, T.S.,Poulsen, S.-A. (deposition date: 2016-11-17, release date: 2017-08-30, Last modification date: 2024-03-06)
Primary citation	Chrysanthopoulos, P.K.,Mujumdar, P.,Woods, L.A.,Dolezal, O.,Ren, B.,Peat, T.S.,Poulsen, S.A. Identification of a New Zinc Binding Chemotype by Fragment Screening. J. Med. Chem., 60:7333-7349, 2017 Cited by PubMed: 28817930 DOI: 10.1021/acs.jmedchem.7b00606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.206 Å)

Structure validation