5TXF

Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in a closed conformation

5TXF の概要

• エントリーDOI: 10.2210/pdb5txf/pdb
• 分子名称: Phosphatidylcholine-sterol acyltransferase, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: acyltransferase, cholesterol, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 195467.34

構造登録者

Manthei, K.A.,Glukhova, A.,Tesmer, J.J.G. (登録日: 2016-11-16, 公開日: 2017-10-25, 最終更新日: 2023-10-04)

• 主引用文献: Manthei, K.A.,Ahn, J.,Glukhova, A.,Yuan, W.,Larkin, C.,Manett, T.D.,Chang, L.,Shayman, J.A.,Axley, M.J.,Schwendeman, A.,Tesmer, J.J.G.; A retractable lid in lecithin:cholesterol acyltransferase provides a structural mechanism for activation by apolipoprotein A-I.; J. Biol. Chem., 292:20313-20327, 2017; PubMed: 29030428; DOI: 10.1074/jbc.M117.802736

実験手法

X-RAY DIFFRACTION (3.1 Å)