5TWX

Crystal Structure of BRD9 bromodomain

5TWX の概要

• エントリーDOI: 10.2210/pdb5twx/pdb
• 分子名称: Bromodomain-containing protein 9, N-[6-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)hexyl]-2-(4-{2-[N-(1,1-dioxo-1lambda~6~-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl}-2-methoxyphenoxy)acetamide (3 entities in total)
• 機能のキーワード: bromodomain, inhibitor, chemical degradation, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58731.82

構造登録者

Seo, H.-S.,Dhe-Paganon, S. (登録日: 2016-11-15, 公開日: 2017-09-27, 最終更新日: 2023-10-04)

• 主引用文献: Remillard, D.,Buckley, D.L.,Paulk, J.,Brien, G.L.,Sonnett, M.,Seo, H.S.,Dastjerdi, S.,Wuhr, M.,Dhe-Paganon, S.,Armstrong, S.A.,Bradner, J.E.; Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.; Angew. Chem. Int. Ed. Engl., 56:5738-5743, 2017; PubMed: 28418626; DOI: 10.1002/anie.201611281

実験手法

X-RAY DIFFRACTION (2.55 Å)