5TVF

Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215

Summary for 5TVF

• Entry DOI: 10.2210/pdb5tvf/pdb
• Related: 5TVM 5TVO
• Descriptor: S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, S-adenosylmethionine decarboxylase proenzyme-like, putative, ... (7 entities in total)
• Functional Keywords: adometdc, cgp40215, decarboxylase, allostery, pseudoenzyme, prozyme, lyase
• Biological source: Trypanosoma brucei brucei (strain 927/4 GUTat10.1); More
• Total number of polymer chains: 6
• Total formula weight: 157901.74

Authors

Phillips, M.A.,Volkov, O.A.,Chen, Z.,Tomchick, D.R. (deposition date: 2016-11-08, release date: 2017-01-11, Last modification date: 2023-11-15)

• Primary citation: Volkov, O.A.,Kinch, L.,Ariagno, C.,Deng, X.,Zhong, S.,Grishin, N.,Tomchick, D.R.,Chen, Z.,Phillips, M.A.; Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.; Elife, 5:-, 2016; PubMed: 27977001; DOI: 10.7554/eLife.20198

Experimental method

X-RAY DIFFRACTION (2.42 Å)