5TVF
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
A | 0008295 | biological_process | spermidine biosynthetic process |
B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
B | 0008295 | biological_process | spermidine biosynthetic process |
C | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
C | 0008295 | biological_process | spermidine biosynthetic process |
D | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
D | 0008295 | biological_process | spermidine biosynthetic process |
E | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
E | 0005829 | cellular_component | cytosol |
E | 0006597 | biological_process | spermine biosynthetic process |
E | 0008295 | biological_process | spermidine biosynthetic process |
E | 0016829 | molecular_function | lyase activity |
F | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
F | 0005829 | cellular_component | cytosol |
F | 0006597 | biological_process | spermine biosynthetic process |
F | 0008295 | biological_process | spermidine biosynthetic process |
F | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue B3P B 401 |
Chain | Residue |
A | GLU36 |
B | ASP189 |
B | ALA190 |
B | PHE304 |
B | ASP306 |
B | TYR341 |
B | HOH520 |
A | ILE38 |
B | ARG94 |
B | GLU124 |
B | TRP125 |
B | VAL181 |
B | SER185 |
B | CYS186 |
B | SER187 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue CGQ B 402 |
Chain | Residue |
A | PHE28 |
A | LEU83 |
B | PYR86 |
B | CYS100 |
B | TYR243 |
B | PRO245 |
B | CYS246 |
B | SER249 |
B | HIS262 |
B | ILE263 |
B | THR264 |
B | GLU266 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue PUT B 403 |
Chain | Residue |
A | SER9 |
A | ALA12 |
B | HIS130 |
B | TYR133 |
B | MET146 |
B | HIS172 |
site_id | AC4 |
Number of Residues | 10 |
Details | binding site for residue B3P D 401 |
Chain | Residue |
C | GLU36 |
D | ARG94 |
D | GLU124 |
D | TRP125 |
D | SER187 |
D | ASP189 |
D | PHE304 |
D | ASP306 |
D | TYR341 |
D | HOH503 |
site_id | AC5 |
Number of Residues | 13 |
Details | binding site for residue CGQ D 402 |
Chain | Residue |
C | ARG26 |
C | PHE28 |
C | LEU83 |
D | PYR86 |
D | CYS100 |
D | TYR243 |
D | PRO245 |
D | CYS246 |
D | SER249 |
D | HIS262 |
D | ILE263 |
D | THR264 |
D | GLU266 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue PUT D 403 |
Chain | Residue |
C | ALA12 |
C | SER16 |
D | HIS130 |
D | ASN132 |
D | TYR133 |
D | PRO136 |
D | MET146 |
D | HIS172 |
site_id | AC7 |
Number of Residues | 9 |
Details | binding site for residue PUT E 401 |
Chain | Residue |
E | GLU42 |
E | ASN44 |
E | TRP126 |
E | GLU193 |
E | ASP195 |
E | ASP282 |
E | TYR314 |
E | HOH506 |
E | HOH511 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue PUT F 401 |
Chain | Residue |
F | GLU42 |
F | ASN44 |
F | TRP126 |
F | GLU193 |
F | ASP195 |
F | ASP282 |
F | TYR314 |
F | HOH519 |