5TVF
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| A | 0008295 | biological_process | spermidine biosynthetic process |
| B | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| B | 0008295 | biological_process | spermidine biosynthetic process |
| C | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| C | 0008295 | biological_process | spermidine biosynthetic process |
| D | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| D | 0008295 | biological_process | spermidine biosynthetic process |
| E | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006596 | biological_process | polyamine biosynthetic process |
| E | 0006597 | biological_process | spermine biosynthetic process |
| E | 0008295 | biological_process | spermidine biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0004014 | molecular_function | adenosylmethionine decarboxylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006596 | biological_process | polyamine biosynthetic process |
| F | 0006597 | biological_process | spermine biosynthetic process |
| F | 0008295 | biological_process | spermidine biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue B3P B 401 |
| Chain | Residue |
| A | GLU36 |
| B | ASP189 |
| B | ALA190 |
| B | PHE304 |
| B | ASP306 |
| B | TYR341 |
| B | HOH520 |
| A | ILE38 |
| B | ARG94 |
| B | GLU124 |
| B | TRP125 |
| B | VAL181 |
| B | SER185 |
| B | CYS186 |
| B | SER187 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue CGQ B 402 |
| Chain | Residue |
| A | PHE28 |
| A | LEU83 |
| B | PYR86 |
| B | CYS100 |
| B | TYR243 |
| B | PRO245 |
| B | CYS246 |
| B | SER249 |
| B | HIS262 |
| B | ILE263 |
| B | THR264 |
| B | GLU266 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue PUT B 403 |
| Chain | Residue |
| A | SER9 |
| A | ALA12 |
| B | HIS130 |
| B | TYR133 |
| B | MET146 |
| B | HIS172 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue B3P D 401 |
| Chain | Residue |
| C | GLU36 |
| D | ARG94 |
| D | GLU124 |
| D | TRP125 |
| D | SER187 |
| D | ASP189 |
| D | PHE304 |
| D | ASP306 |
| D | TYR341 |
| D | HOH503 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue CGQ D 402 |
| Chain | Residue |
| C | ARG26 |
| C | PHE28 |
| C | LEU83 |
| D | PYR86 |
| D | CYS100 |
| D | TYR243 |
| D | PRO245 |
| D | CYS246 |
| D | SER249 |
| D | HIS262 |
| D | ILE263 |
| D | THR264 |
| D | GLU266 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue PUT D 403 |
| Chain | Residue |
| C | ALA12 |
| C | SER16 |
| D | HIS130 |
| D | ASN132 |
| D | TYR133 |
| D | PRO136 |
| D | MET146 |
| D | HIS172 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue PUT E 401 |
| Chain | Residue |
| E | GLU42 |
| E | ASN44 |
| E | TRP126 |
| E | GLU193 |
| E | ASP195 |
| E | ASP282 |
| E | TYR314 |
| E | HOH506 |
| E | HOH511 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue PUT F 401 |
| Chain | Residue |
| F | GLU42 |
| F | ASN44 |
| F | TRP126 |
| F | GLU193 |
| F | ASP195 |
| F | ASP282 |
| F | TYR314 |
| F | HOH519 |
