5TVF
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | S-adenosylmethionine decarboxylase beta chain | polymer | 85 | 9754.1 | 2 | UniProt (Q587A7) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
| 2 | B, D (B, D) | S-adenosylmethionine decarboxylase alpha chain | polymer | 285 | 32042.0 | 2 | UniProt (Q587A7) Pfam (PF01536) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
| 3 | E, F (E, F) | S-adenosylmethionine decarboxylase proenzyme-like, putative | polymer | 325 | 36343.7 | 2 | UniProt (Q587B3) Pfam (PF01536) | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) | |
| 4 | G, J (B, D) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 2 | Chemie (B3P) | |||
| 5 | H, K (B, D) | 3-[C-[N'-(3-CARBAMIMIDOYL-BENZYLIDENIUM)-HYDRAZINO]-[[AMINOMETHYLIDENE]AMINIUM]-IMINOMETHYL]-BENZAMIDINIUM | non-polymer | 352.4 | 2 | Chemie (CGQ) | |||
| 6 | I, L, M, N (B, D, E, F) | 1,4-DIAMINOBUTANE | non-polymer | 88.2 | 4 | Chemie (PUT) | |||
| 7 | O, P, Q, R, S... (A, B, C, D, E...) | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
B, D: 87 - 370 (UniProt: Q587A7)
| PDB | External Database | Details |
|---|---|---|
| Pyr 86 | - | See Remark 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 156279.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1622.1 | |
| All* | Total formula weight | 157901.7 |
