5TVF

Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215

5TVF の概要

• エントリーDOI: 10.2210/pdb5tvf/pdb
• 関連するPDBエントリー: 5TVM 5TVO
• 分子名称: S-adenosylmethionine decarboxylase beta chain, S-adenosylmethionine decarboxylase alpha chain, S-adenosylmethionine decarboxylase proenzyme-like, putative, ... (7 entities in total)
• 機能のキーワード: adometdc, cgp40215, decarboxylase, allostery, pseudoenzyme, prozyme, lyase
• 由来する生物種: Trypanosoma brucei brucei (strain 927/4 GUTat10.1); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 157901.74

構造登録者

Phillips, M.A.,Volkov, O.A.,Chen, Z.,Tomchick, D.R. (登録日: 2016-11-08, 公開日: 2017-01-11, 最終更新日: 2023-11-15)

• 主引用文献: Volkov, O.A.,Kinch, L.,Ariagno, C.,Deng, X.,Zhong, S.,Grishin, N.,Tomchick, D.R.,Chen, Z.,Phillips, M.A.; Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.; Elife, 5:-, 2016; PubMed: 27977001; DOI: 10.7554/eLife.20198

実験手法

X-RAY DIFFRACTION (2.42 Å)