5TUY

Structure of human G9a SET-domain (EHMT2) in complex with inhibitor MS0124

Summary for 5TUY

Entry DOI	10.2210/pdb5tuy/pdb
Related	5TUZ
Descriptor	Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywords	methyl-transferase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	63877.07
Authors	Babault, N.,Xiong, Y.,Liu, J.,Jin, J. (deposition date: 2016-11-07, release date: 2017-02-22, Last modification date: 2023-10-04)
Primary citation	Xiong, Y.,Li, F.,Babault, N.,Dong, A.,Zeng, H.,Wu, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J. Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J. Med. Chem., 60:1876-1891, 2017 Cited by PubMed: 28135087 DOI: 10.1021/acs.jmedchem.6b01645 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation