5TUY
Structure of human G9a SET-domain (EHMT2) in complex with inhibitor MS0124
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Histone-lysine N-methyltransferase EHMT2 | polymer | 268 | 30891.0 | 2 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) In PDB | Homo sapiens (Human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | A, B | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 4 | A, B | 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine | non-polymer | 387.5 | 2 | Chemie (7L6) | |||
| 5 | water | water | 18.0 | 101 | Chemie (HOH) |
Sequence modifications
A, B: 921 - 1188 (UniProt: Q96KQ7)
| PDB | External Database | Details |
|---|---|---|
| Lys 1188 | Arg 1154 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61782.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2095.1 | |
| All* | Total formula weight | 63877.1 |
