5TTF
Crystal structure of catalytic domain of G9a with MS012
Summary for 5TTF
Entry DOI | 10.2210/pdb5ttf/pdb |
Related | 5TTG |
Descriptor | Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ... (7 entities in total) |
Functional Keywords | ehmt2, g9a, bat8, methyltransferase, unc3832, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q96KQ7 |
Total number of polymer chains | 4 |
Total formula weight | 134878.89 |
Authors | DONG, A.,ZENG, H.,LIU, J.,XIONG, Y.,BABAULT, N.,JIN, J.,TEMPEL, W.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,WU, H.,BROWN, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-11-03, release date: 2016-12-21, Last modification date: 2023-10-04) |
Primary citation | Xiong, Y.,Li, F.,Babault, N.,Dong, A.,Zeng, H.,Wu, H.,Chen, X.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J. Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J. Med. Chem., 60:1876-1891, 2017 Cited by PubMed: 28135087DOI: 10.1021/acs.jmedchem.6b01645 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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