5TTF

Crystal structure of catalytic domain of G9a with MS012

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002039	molecular_function	p53 binding
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
B	0002039	molecular_function	p53 binding
B	0005634	cellular_component	nucleus
B	0008270	molecular_function	zinc ion binding
B	0016279	molecular_function	protein-lysine N-methyltransferase activity
B	0042054	molecular_function	histone methyltransferase activity
C	0002039	molecular_function	p53 binding
C	0005634	cellular_component	nucleus
C	0008270	molecular_function	zinc ion binding
C	0016279	molecular_function	protein-lysine N-methyltransferase activity
C	0042054	molecular_function	histone methyltransferase activity
D	0002039	molecular_function	p53 binding
D	0005634	cellular_component	nucleus
D	0008270	molecular_function	zinc ion binding
D	0016279	molecular_function	protein-lysine N-methyltransferase activity
D	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1501

Chain	Residue
A	CYS974
A	CYS987
A	CYS1017
A	CYS1021

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1502

Chain	Residue
A	CYS980
A	CYS1017
A	CYS1023
A	CYS1027

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1503

Chain	Residue
A	CYS976
A	CYS980
A	CYS985
A	CYS974

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1504

Chain	Residue
A	CYS1115
A	CYS1168
A	CYS1170
A	CYS1175

---

site_id	AC5
Number of Residues	19
Details	binding site for residue SAM A 1505

Chain	Residue
A	MET1048
A	TRP1050
A	SER1084
A	TYR1085
A	ARG1109
A	PHE1110
A	ASN1112
A	HIS1113
A	TYR1154
A	PHE1158
A	PHE1166
A	THR1167
A	CYS1168
A	GLN1169
A	HOH1608
A	HOH1651
A	HOH1657
A	HOH1672
A	HOH1673

---

site_id	AC6
Number of Residues	7
Details	binding site for residue 7KZ A 1506

Chain	Residue
A	ASP1078
A	ASP1083
A	LEU1086
A	ASP1088
A	CYS1098
A	ARG1157
A	PHE1158

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 1507

Chain	Residue
A	ASN963
A	ARG1132
D	ARG1039

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 1501

Chain	Residue
B	CYS974
B	CYS987
B	CYS1017
B	CYS1021

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN B 1502

Chain	Residue
B	CYS980
B	CYS1017
B	CYS1023
B	CYS1027

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 1503

Chain	Residue
B	CYS974
B	CYS976
B	CYS980
B	CYS985

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN B 1504

Chain	Residue
B	CYS1115
B	CYS1168
B	CYS1170
B	CYS1175

---

site_id	AD3
Number of Residues	16
Details	binding site for residue SAM B 1505

Chain	Residue
B	MET1048
B	TRP1050
B	SER1084
B	TYR1085
B	ARG1109
B	PHE1110
B	ASN1112
B	HIS1113
B	TYR1154
B	PHE1158
B	PHE1166
B	THR1167
B	CYS1168
B	GLN1169
B	HOH1615
B	HOH1699

---

site_id	AD4
Number of Residues	9
Details	binding site for residue 7KZ B 1506

Chain	Residue
B	ALA1077
B	ASP1078
B	ARG1080
B	ASP1083
B	LEU1086
B	ASP1088
B	CYS1098
B	ARG1157
B	PHE1158

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN C 1501

Chain	Residue
C	CYS974
C	CYS987
C	CYS1017
C	CYS1021

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN C 1502

Chain	Residue
C	CYS980
C	CYS1017
C	CYS1023
C	CYS1027

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN C 1503

Chain	Residue
C	CYS974
C	CYS976
C	CYS980
C	CYS985

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN C 1504

Chain	Residue
C	CYS1168
C	CYS1170
C	CYS1175
C	CYS1115

---

site_id	AD9
Number of Residues	15
Details	binding site for residue SAM C 1505

Chain	Residue
C	MET1048
C	TRP1050
C	SER1084
C	TYR1085
C	ARG1109
C	PHE1110
C	ASN1112
C	HIS1113
C	TYR1154
C	PHE1158
C	PHE1166
C	CYS1168
C	GLN1169
C	HOH1606
C	HOH1714

---

site_id	AE1
Number of Residues	8
Details	binding site for residue 7KZ C 1506

Chain	Residue
C	ALA1077
C	ASP1078
C	ASP1083
C	LEU1086
C	ASP1088
C	CYS1098
C	ARG1157
C	PHE1158

---

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN D 1501

Chain	Residue
D	CYS974
D	CYS987
D	CYS1017
D	CYS1021

---

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN D 1502

Chain	Residue
D	CYS980
D	CYS1017
D	CYS1023
D	CYS1027

---

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN D 1503

Chain	Residue
D	CYS974
D	CYS976
D	CYS980
D	CYS985

---

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN D 1504

Chain	Residue
D	CYS1115
D	CYS1168
D	CYS1170
D	CYS1175

---

site_id	AE6
Number of Residues	17
Details	binding site for residue SAM D 1505

Chain	Residue
D	MET1048
D	GLY1049
D	TRP1050
D	SER1084
D	TYR1085
D	ARG1109
D	PHE1110
D	ASN1112
D	HIS1113
D	TYR1154
D	PHE1158
D	PHE1166
D	CYS1168
D	GLN1169
D	HOH1627
D	HOH1667
D	HOH1678

---

site_id	AE7
Number of Residues	8
Details	binding site for residue 7KZ D 1506

Chain	Residue
D	ASP1074
D	ARG1080
D	ASP1083
D	LEU1086
D	ASP1088
D	CYS1098
D	ARG1157
D	PHE1158

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	Domain: {"description":"Pre-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00157","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Domain: {"description":"Post-SET"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"Interaction with histone H3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	72
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Histone H3K9me binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---