Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5TTF

Crystal structure of catalytic domain of G9a with MS012

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002039	molecular_function	p53 binding
A	0005634	cellular_component	nucleus
A	0008270	molecular_function	zinc ion binding
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
B	0002039	molecular_function	p53 binding
B	0005634	cellular_component	nucleus
B	0008270	molecular_function	zinc ion binding
B	0016279	molecular_function	protein-lysine N-methyltransferase activity
B	0042054	molecular_function	histone methyltransferase activity
C	0002039	molecular_function	p53 binding
C	0005634	cellular_component	nucleus
C	0008270	molecular_function	zinc ion binding
C	0016279	molecular_function	protein-lysine N-methyltransferase activity
C	0042054	molecular_function	histone methyltransferase activity
D	0002039	molecular_function	p53 binding
D	0005634	cellular_component	nucleus
D	0008270	molecular_function	zinc ion binding
D	0016279	molecular_function	protein-lysine N-methyltransferase activity
D	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1501

Chain	Residue
A	CYS974
A	CYS987
A	CYS1017
A	CYS1021

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1502

Chain	Residue
A	CYS980
A	CYS1017
A	CYS1023
A	CYS1027

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1503

Chain	Residue
A	CYS976
A	CYS980
A	CYS985
A	CYS974

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1504

Chain	Residue
A	CYS1115
A	CYS1168
A	CYS1170
A	CYS1175

site_id	AC5
Number of Residues	19
Details	binding site for residue SAM A 1505

Chain	Residue
A	MET1048
A	TRP1050
A	SER1084
A	TYR1085
A	ARG1109
A	PHE1110
A	ASN1112
A	HIS1113
A	TYR1154
A	PHE1158
A	PHE1166
A	THR1167
A	CYS1168
A	GLN1169
A	HOH1608
A	HOH1651
A	HOH1657
A	HOH1672
A	HOH1673

site_id	AC6
Number of Residues	7
Details	binding site for residue 7KZ A 1506

Chain	Residue
A	ASP1078
A	ASP1083
A	LEU1086
A	ASP1088
A	CYS1098
A	ARG1157
A	PHE1158

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 1507

Chain	Residue
A	ASN963
A	ARG1132
D	ARG1039

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN B 1501

Chain	Residue
B	CYS974
B	CYS987
B	CYS1017
B	CYS1021

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN B 1502

Chain	Residue
B	CYS980
B	CYS1017
B	CYS1023
B	CYS1027

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 1503

Chain	Residue
B	CYS974
B	CYS976
B	CYS980
B	CYS985

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN B 1504

Chain	Residue
B	CYS1115
B	CYS1168
B	CYS1170
B	CYS1175

site_id	AD3
Number of Residues	16
Details	binding site for residue SAM B 1505

Chain	Residue
B	MET1048
B	TRP1050
B	SER1084
B	TYR1085
B	ARG1109
B	PHE1110
B	ASN1112
B	HIS1113
B	TYR1154
B	PHE1158
B	PHE1166
B	THR1167
B	CYS1168
B	GLN1169
B	HOH1615
B	HOH1699

site_id	AD4
Number of Residues	9
Details	binding site for residue 7KZ B 1506

Chain	Residue
B	ALA1077
B	ASP1078
B	ARG1080
B	ASP1083
B	LEU1086
B	ASP1088
B	CYS1098
B	ARG1157
B	PHE1158

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN C 1501

Chain	Residue
C	CYS974
C	CYS987
C	CYS1017
C	CYS1021

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN C 1502

Chain	Residue
C	CYS980
C	CYS1017
C	CYS1023
C	CYS1027

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN C 1503

Chain	Residue
C	CYS974
C	CYS976
C	CYS980
C	CYS985

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN C 1504

Chain	Residue
C	CYS1168
C	CYS1170
C	CYS1175
C	CYS1115

site_id	AD9
Number of Residues	15
Details	binding site for residue SAM C 1505

Chain	Residue
C	MET1048
C	TRP1050
C	SER1084
C	TYR1085
C	ARG1109
C	PHE1110
C	ASN1112
C	HIS1113
C	TYR1154
C	PHE1158
C	PHE1166
C	CYS1168
C	GLN1169
C	HOH1606
C	HOH1714

site_id	AE1
Number of Residues	8
Details	binding site for residue 7KZ C 1506

Chain	Residue
C	ALA1077
C	ASP1078
C	ASP1083
C	LEU1086
C	ASP1088
C	CYS1098
C	ARG1157
C	PHE1158

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN D 1501

Chain	Residue
D	CYS974
D	CYS987
D	CYS1017
D	CYS1021

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN D 1502

Chain	Residue
D	CYS980
D	CYS1017
D	CYS1023
D	CYS1027

site_id	AE4
Number of Residues	4
Details	binding site for residue ZN D 1503

Chain	Residue
D	CYS974
D	CYS976
D	CYS980
D	CYS985

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN D 1504

Chain	Residue
D	CYS1115
D	CYS1168
D	CYS1170
D	CYS1175

site_id	AE6
Number of Residues	17
Details	binding site for residue SAM D 1505

Chain	Residue
D	MET1048
D	GLY1049
D	TRP1050
D	SER1084
D	TYR1085
D	ARG1109
D	PHE1110
D	ASN1112
D	HIS1113
D	TYR1154
D	PHE1158
D	PHE1166
D	CYS1168
D	GLN1169
D	HOH1627
D	HOH1667
D	HOH1678

site_id	AE7
Number of Residues	8
Details	binding site for residue 7KZ D 1506

Chain	Residue
D	ASP1074
D	ARG1080
D	ASP1083
D	LEU1086
D	ASP1088
D	CYS1098
D	ARG1157
D	PHE1158

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	BINDING:

Chain	Residue	Details
A	LYS1008
A	ASP1082
A	ILE1119
A	THR1146
A	GLU1149
B	LYS1008
B	GLU1010
B	ILE1014
B	GLN1019
B	CYS1021
B	GLY1051
A	GLU1010
B	LEU1055
B	THR1057
B	GLY1061
B	ASP1082
B	ILE1119
B	THR1146
B	GLU1149
C	LYS1008
C	GLU1010
C	ILE1014
A	ILE1014
C	GLN1019
C	CYS1021
C	GLY1051
C	LEU1055
C	THR1057
C	GLY1061
C	ASP1082
C	ILE1119
C	THR1146
C	GLU1149
A	GLN1019
D	LYS1008
D	GLU1010
D	ILE1014
D	GLN1019
D	CYS1021
D	GLY1051
D	LEU1055
D	THR1057
D	GLY1061
D	ASP1082
A	CYS1021
D	ILE1119
D	THR1146
D	GLU1149
A	GLY1051
A	LEU1055
A	THR1057
A	GLY1061

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Histone H3K9me binding => ECO:0000250

Chain	Residue	Details
A	ALA1101
B	ALA1101
C	ALA1101
D	ALA1101

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)