5TTF
Crystal structure of catalytic domain of G9a with MS012
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase EHMT2 | polymer | 283 | 32604.9 | 4 | UniProt (Q96KQ7) Pfam (PF05033) Pfam (PF00856) | Homo sapiens (Human) | Euchromatic histone-lysine N-methyltransferase 2,HLA-B-associated transcript 8,Histone H3-K9 methyltransferase 3,H3-K9-HMTase 3,Lysine N-methyltransferase 1C,Protein G9a |
| 2 | BA, CA, DA, E, EA... (D, A, B, C) | ZINC ION | non-polymer | 65.4 | 16 | Chemie (ZN) | |||
| 3 | FA, I, Q, Y (D, A, B, C) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
| 4 | GA, J, R, Z (D, A, B, C) | N4-(1-methylpiperidin-4-yl)-N2-hexyl-6,7-dimethoxyquinazoline-2,4-diamine | non-polymer | 401.5 | 4 | Chemie (7KZ) | |||
| 5 | K (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | AA, HA, L, S, T (C, D, A, B) | UNKNOWN ATOM OR ION | non-polymer | 35.5 | 5 | Chemie (UNX) | |||
| 7 | IA, JA, KA, LA (A, B, C, D) | water | water | 18.0 | 586 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 913 - 1193 (UniProt: Q96KQ7)
| PDB | External Database | Details |
|---|---|---|
| Gly 911 | - | expression tag |
| Ser 912 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130419.7 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 4459.2 | |
| All* | Total formula weight | 134878.9 |
