5TS0

Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2208

Summary for 5TS0

• Entry DOI: 10.2210/pdb5ts0/pdb
• Related: 5TRG 5TRR 5TRS 5TRY
• Related PRD ID: PRD_002253
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, (2S)-N-{(2S)-3-methoxy-1-[(naphthalen-1-ylmethyl)amino]-1-oxopropan-2-yl}-4-oxo-2-[(3-phenylpropanoyl)amino]-4-(1H-pyrrol-1-yl)butanamide (non-preferred name), ... (4 entities in total)
• Functional Keywords: n, c-capped dipeptides, mycobacterium tuberculosis, proteasome, inhibitors, hydronlase-hydrolase inhibitor complex, hydronlase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 28
• Total formula weight: 725212.25

Authors

Hsu, H.-C.,Fan, H.,Singh, P.K.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. (deposition date: 2016-10-27, release date: 2017-01-11, Last modification date: 2024-03-06)

• Primary citation: Hsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H.; Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.; Biochemistry, 56:324-333, 2017; PubMed: 27976853; DOI: 10.1021/acs.biochem.6b01107

Experimental method

X-RAY DIFFRACTION (2.84679745871 Å)