5TS0

Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2208

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Proteasome subunit alpha	polymer	240	25972.0	14	UniProt (A5U4D5) Pfam (PF00227) UniProt (by SIFTS) (P9WHU1)	Mycobacterium tuberculosis	20S proteasome alpha subunit,Proteasome core protein PrcA
2	AA, BA, H, I, J... (H, I, J, K, L...)	Proteasome subunit beta	polymer	240	25274.3	14	UniProt (A5U4D6) Pfam (PF00227) UniProt (by SIFTS) (P9WHT9)	Mycobacterium tuberculosis	20S proteasome beta subunit,Proteasome core protein PrcB
3	CA, DA, EA, FA, GA... (H, I, J, K, L...)	(2S)-N-{(2S)-3-methoxy-1-[(naphthalen-1-ylmethyl)amino]-1-oxopropan-2-yl}-4-oxo-2-[(3-phenylpropanoyl)amino]-4-(1H-pyrrol-1-yl)butanamide (non-preferred name)	non-polymer		554.6	14	BIRD (PRD_002253) Chemie (7J1)
4	AB, BB, CB, DB, EB... (K, L, M, N, O...)	water	water		18.0	348	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, O, P, Q, R, S, T, U: 10 - 248 (UniProt: A5U4D5)

PDB	External Database	Details
Met 9	-	initiating methionine

H, I, J, K, L, M, N, V, W, X, Y, Z, a, b: 1 - 234 (UniProt: A5U4D6)

PDB	External Database	Details
His 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	717447.3
Non-Polymers*	Number of molecules	14
	Total formula weight	7764.9
All*	Total formula weight	725212.2

*Water molecules are not included.