5TRY

Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2206

Summary for 5TRY

• Entry DOI: 10.2210/pdb5try/pdb
• Related: 5TRG 5TRR 5TRS 5TS0
• Related PRD ID: PRD_002254
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, (2~{S})-~{N}-[(2~{S})-3-methoxy-1-(naphthalen-1-ylmethylamino)-1-oxidanylidene-propan-2-yl]-4-oxidanylidene-2-(3-phenylpropanoylamino)-4-piperidin-1-yl-butanamide, ... (4 entities in total)
• Functional Keywords: n, c-capped dipeptides, mycobacterium tuberculosis, proteasome, inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 28
• Total formula weight: 725465.06

Authors

Hsu, H.-C.,Fan, H.,Singh, P.K.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. (deposition date: 2016-10-27, release date: 2017-01-11, Last modification date: 2023-10-04)

• Primary citation: Hsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H.; Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.; Biochemistry, 56:324-333, 2017; PubMed: 27976853; DOI: 10.1021/acs.biochem.6b01107

Experimental method

X-RAY DIFFRACTION (3.00000818194 Å)