5TRU

Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4

5TRU の概要

• エントリーDOI: 10.2210/pdb5tru/pdb
• 分子名称: Ipilimumab Fab light chain, Ipilimumab Fab heavy chain, Cytotoxic T-lymphocyte protein 4 (3 entities in total)
• 機能のキーワード: antibody, complex, fab, immune system
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P16410
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 120693.16

構造登録者

Ramagopal, U.A.,Liu, W.,Garrett-Thomson, S.C.,Yan, Q.,Srinivasan, M.,Wong, S.C.,Bell, A.,Mankikar, S.,Rangan, V.S.,Deshpande, S.,Bonanno, J.B.,Korman, A.J.,Almo, S.C. (登録日: 2016-10-27, 公開日: 2017-05-10, 最終更新日: 2023-10-04)

• 主引用文献: Ramagopal, U.A.,Liu, W.,Garrett-Thomson, S.C.,Bonanno, J.B.,Yan, Q.,Srinivasan, M.,Wong, S.C.,Bell, A.,Mankikar, S.,Rangan, V.S.,Deshpande, S.,Korman, A.J.,Almo, S.C.; Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.; Proc. Natl. Acad. Sci. U.S.A., 114:E4223-E4232, 2017; PubMed: 28484017; DOI: 10.1073/pnas.1617941114

実験手法

X-RAY DIFFRACTION (3 Å)