5TRG
Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2
Summary for 5TRG
Entry DOI | 10.2210/pdb5trg/pdb |
Related | 5TRR 5TRS 5TRY 5TS0 |
Related PRD ID | PRD_002252 |
Descriptor | Proteasome subunit alpha, Proteasome subunit beta, N,N-diethyl-N~2~-[(2E)-3-phenylprop-2-enoyl]-L-asparaginyl-4-fluoro-N-[(naphthalen-1-yl)methyl]-L-phenylalaninamide, ... (4 entities in total) |
Functional Keywords | n, c-capped dipeptides, mycobacterium tuberculosis, dplg-2, proteasome inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Mycobacterium tuberculosis More |
Total number of polymer chains | 28 |
Total formula weight | 726165.54 |
Authors | Hsu, H.-C.,Fan, H.,Singh, R.K.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. (deposition date: 2016-10-26, release date: 2017-01-11, Last modification date: 2023-10-04) |
Primary citation | Hsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome. Biochemistry, 56:324-333, 2017 Cited by PubMed: 27976853DOI: 10.1021/acs.biochem.6b01107 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.804 Å) |
Structure validation
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