5TRG

Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2

Summary for 5TRG

• Entry DOI: 10.2210/pdb5trg/pdb
• Related: 5TRR 5TRS 5TRY 5TS0
• Related PRD ID: PRD_002252
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, N,N-diethyl-N~2~-[(2E)-3-phenylprop-2-enoyl]-L-asparaginyl-4-fluoro-N-[(naphthalen-1-yl)methyl]-L-phenylalaninamide, ... (4 entities in total)
• Functional Keywords: n, c-capped dipeptides, mycobacterium tuberculosis, dplg-2, proteasome inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis; More
• Total number of polymer chains: 28
• Total formula weight: 726165.54

Authors

Hsu, H.-C.,Fan, H.,Singh, R.K.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H. (deposition date: 2016-10-26, release date: 2017-01-11, Last modification date: 2023-10-04)

• Primary citation: Hsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H.; Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.; Biochemistry, 56:324-333, 2017; PubMed: 27976853; DOI: 10.1021/acs.biochem.6b01107

Experimental method

X-RAY DIFFRACTION (2.804 Å)