5TRF
MDM2 in complex with SAR405838
Summary for 5TRF
Entry DOI | 10.2210/pdb5trf/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | p53-binding protein, oncoprotein, double minute 2 protein, small molecule inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 5 |
Total formula weight | 66277.12 |
Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2016-10-26, release date: 2016-11-09, Last modification date: 2024-03-06) |
Primary citation | Wang, S.,Sun, W.,Zhao, Y.,McEachern, D.,Meaux, I.,Barriere, C.,Stuckey, J.A.,Meagher, J.L.,Bai, L.,Liu, L.,Hoffman-Luca, C.G.,Lu, J.,Shangary, S.,Yu, S.,Bernard, D.,Aguilar, A.,Dos-Santos, O.,Besret, L.,Guerif, S.,Pannier, P.,Gorge-Bernat, D.,Debussche, L. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res., 74:5855-5865, 2014 Cited by PubMed: 25145672DOI: 10.1158/0008-5472.CAN-14-0799 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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