5TQE

Factor VIIa in complex with the inhibitor (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene-4,14-dione

5TQE の概要

• エントリーDOI: 10.2210/pdb5tqe/pdb
• 関連するPDBエントリー: 5TQF 5TQG
• 分子名称: Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene-4,14-dione, ... (7 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P08709 P08709
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35420.37

構造登録者

Wei, A. (登録日: 2016-10-24, 公開日: 2017-02-01, 最終更新日: 2023-10-04)

• 主引用文献: Richter, J.M.,Cheney, D.L.,Bates, J.A.,Wei, A.,Luettgen, J.M.,Rendina, A.R.,Harper, T.M.,Narayanan, R.,Wong, P.C.,Seiffert, D.,Wexler, R.R.,Priestley, E.S.; Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors.; ACS Med Chem Lett, 8:67-72, 2017; PubMed: 28105277; DOI: 10.1021/acsmedchemlett.6b00375

実験手法

X-RAY DIFFRACTION (1.9 Å)