5TQE
Factor VIIa in complex with the inhibitor (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene-4,14-dione
Summary for 5TQE
Entry DOI | 10.2210/pdb5tqe/pdb |
Related | 5TQF 5TQG |
Descriptor | Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaene-4,14-dione, ... (7 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35420.37 |
Authors | |
Primary citation | Richter, J.M.,Cheney, D.L.,Bates, J.A.,Wei, A.,Luettgen, J.M.,Rendina, A.R.,Harper, T.M.,Narayanan, R.,Wong, P.C.,Seiffert, D.,Wexler, R.R.,Priestley, E.S. Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Med Chem Lett, 8:67-72, 2017 Cited by PubMed: 28105277DOI: 10.1021/acsmedchemlett.6b00375 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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