5TQG

Factor VIIa in complex with the inhibitor (5R,11R)-11-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2-difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione

Summary for 5TQG

• Entry DOI: 10.2210/pdb5tqg/pdb
• Related: 5TQE 5TQF
• Descriptor: Factor VIIa (Heavy Chain), Factor VIIa (Light Chain), (5R,11R)-11-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2-difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35608.51

Authors

Wei, A. (deposition date: 2016-10-24, release date: 2017-02-01, Last modification date: 2024-10-23)

Primary citation

Richter, J.M.,Cheney, D.L.,Bates, J.A.,Wei, A.,Luettgen, J.M.,Rendina, A.R.,Harper, T.M.,Narayanan, R.,Wong, P.C.,Seiffert, D.,Wexler, R.R.,Priestley, E.S.
Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors.
ACS Med Chem Lett, 8:67-72, 2017

PubMed Abstract: Two novel series of meta-linked phenylglycine-based macrocyclic FVIIa inhibitors have been designed to improve the rodent metabolic stability and PK observed with the precursor para-linked phenylglycine macrocycles. Through iterative structure-based design and optimization, the TF/FVIIa was improved to subnanomolar levels with good clotting activity, metabolic stability, and permeability.

PubMed: 28105277
DOI: 10.1021/acsmedchemlett.6b00375

Experimental method

X-RAY DIFFRACTION (1.9 Å)