5TOW

Crystal structure of the inactive form of S-adenosyl-L-homocysteine hydrolase from Thermotoga maritima in ternary complex with NADH and Adenosine

Summary for 5TOW

Entry DOI	10.2210/pdb5tow/pdb
Descriptor	Adenosylhomocysteinase, ADENOSINE, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (6 entities in total)
Functional Keywords	regulation of sam-dependent methylation reactions, hydrolase
Biological source	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Total number of polymer chains	2
Total formula weight	91479.46
Authors	Czyrko, J.,Brzezinski, K. (deposition date: 2016-10-19, release date: 2017-07-05, Last modification date: 2024-01-17)
Primary citation	Brzezinski, K.,Czyrko, J.,Sliwiak, J.,Nalewajko-Sieliwoniuk, E.,Jaskolski, M.,Nocek, B.,Dauter, Z. S-adenosyl-L-homocysteine hydrolase from a hyperthermophile (Thermotoga maritima) is expressed in Escherichia coli in inactive form - Biochemical and structural studies. Int. J. Biol. Macromol., 104:584-596, 2017 Cited by PubMed: 28629859 DOI: 10.1016/j.ijbiomac.2017.06.065 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation