5TIU
Crystal structure of SYK kinase domain with inhibitor
Summary for 5TIU
Entry DOI | 10.2210/pdb5tiu/pdb |
Descriptor | Tyrosine-protein kinase SYK, 5-{[(2S)-2-aminopropyl]amino}-3-(1H-indol-2-yl)pyrazine-2-carboxamide (3 entities in total) |
Functional Keywords | carboxamide spleen tyrosine kinase (syk), transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 1 |
Total formula weight | 34194.36 |
Authors | Ellis, J.M.,Altman, M.D.,Cash, B.,Haidle, A.M.,Kubiak, R.L.,Maddess, M.L.,Yan, Y.,Northrup, A.B. (deposition date: 2016-10-03, release date: 2017-01-11, Last modification date: 2024-04-03) |
Primary citation | Ellis, J.M.,Altman, M.D.,Cash, B.,Haidle, A.M.,Kubiak, R.L.,Maddess, M.L.,Yan, Y.,Northrup, A.B. Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization. ACS Med Chem Lett, 7:1151-1155, 2016 Cited by PubMed: 27994755DOI: 10.1021/acsmedchemlett.6b00353 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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