5TFR

Crystal structure of Zika Virus NS5 protein

5TFR の概要

• エントリーDOI: 10.2210/pdb5tfr/pdb
• 分子名称: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ... (4 entities in total)
• 機能のキーワード: mtase, methyltransferase, polymerase, rdrp, rna-dependent rna polymerase, flavivirus, zika, viral protein
• 由来する生物種: Zika virus (strain Mr 766) (ZIKV)
• 細胞内の位置: Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: Q32ZE1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 208186.90

構造登録者

Longenecker, K.L.,Upadhyay, A.K. (登録日: 2016-09-26, 公開日: 2016-10-12, 最終更新日: 2023-10-04)

• 主引用文献: Upadhyay, A.K.,Cyr, M.,Longenecker, K.,Tripathi, R.,Sun, C.,Kempf, D.J.; Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.; Acta Crystallogr F Struct Biol Commun, 73:116-122, 2017; PubMed: 28291746; DOI: 10.1107/S2053230X17001601

実験手法

X-RAY DIFFRACTION (3.05 Å)