5TF5

CRYSTAL STRUCTURE OF HUMAN KAT-2 IN COMPLEX WITH A REVERSIBLE INHIBITOR

Summary for 5TF5

• Entry DOI: 10.2210/pdb5tf5/pdb
• Descriptor: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid (3 entities in total)
• Functional Keywords: ns-1502, reversible kat-2 inhibitor, llp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion : Q8N5Z0
• Total number of polymer chains: 2
• Total formula weight: 95621.28

Authors

Nematollahi, A.,Sun, G.,Church, W.B. (deposition date: 2016-09-24, release date: 2016-10-05, Last modification date: 2023-11-15)

• Primary citation: Nematollahi, A.,Sun, G.,Jayawickrama, G.,Hanrahan, J.R.,Church, W.B.; Crystal structure and mechanistic analysis of a novel human kynurenine aminotransferase-2 reversible inhibitor; Med.Chem.Res., 2017; DOI: 10.1007/s00044-017-1950-6

Experimental method

X-RAY DIFFRACTION (1.807 Å)