5TF5
CRYSTAL STRUCTURE OF HUMAN KAT-2 IN COMPLEX WITH A REVERSIBLE INHIBITOR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005829 | cellular_component | cytosol |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016212 | molecular_function | L-kynurenine:2-oxoglutarate transaminase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0047313 | molecular_function | aromatic-amino-acid:glyoxylate transaminase activity |
| A | 0047315 | molecular_function | L-kynurenine:glyoxylate transaminase activity |
| A | 0047536 | molecular_function | L-2-aminoadipate:2-oxoglutarate transaminase activity |
| A | 0047958 | molecular_function | glycine:2-oxoglutarate transaminase activity |
| A | 0050094 | molecular_function | L-methionine:glyoxylate transaminase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005829 | cellular_component | cytosol |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016212 | molecular_function | L-kynurenine:2-oxoglutarate transaminase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0047313 | molecular_function | aromatic-amino-acid:glyoxylate transaminase activity |
| B | 0047315 | molecular_function | L-kynurenine:glyoxylate transaminase activity |
| B | 0047536 | molecular_function | L-2-aminoadipate:2-oxoglutarate transaminase activity |
| B | 0047958 | molecular_function | glycine:2-oxoglutarate transaminase activity |
| B | 0050094 | molecular_function | L-methionine:glyoxylate transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 7AR B 501 |
| Chain | Residue |
| A | ILE19 |
| B | ASN202 |
| B | TYR233 |
| B | LLP263 |
| B | MET354 |
| B | PHE355 |
| B | LEU382 |
| B | PHE387 |
| B | ARG399 |
| A | MET22 |
| A | GLY39 |
| A | PRO41 |
| A | TYR74 |
| A | HOH783 |
| B | GLN118 |
| B | TYR142 |
| B | SER143 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Transit peptide: {"description":"Mitochondrion","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 54 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9WVM8","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
