5TB5

Crystal structure of full-length farnesylated and methylated KRAS4b in complex with PDE-delta (crystal form I - with partially disordered hypervariable region)

5TB5 の概要

• エントリーDOI: 10.2210/pdb5tb5/pdb
• 分子名称: GTPase KRas, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, FARNESYL, ... (6 entities in total)
• 機能のキーワード: kras4b, pdedelta, pde6delta, ras, kras, oncoprotein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116; Cytoplasm, cytosol : O43924
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 78417.26

構造登録者

Dharmaiah, S.,Tran, T.H.,Simanshu, D.K. (登録日: 2016-09-11, 公開日: 2016-11-02, 最終更新日: 2023-10-04)

• 主引用文献: Dharmaiah, S.,Bindu, L.,Tran, T.H.,Gillette, W.K.,Frank, P.H.,Ghirlando, R.,Nissley, D.V.,Esposito, D.,McCormick, F.,Stephen, A.G.,Simanshu, D.K.; Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.; Proc.Natl.Acad.Sci.USA, 113:E6766-E6775, 2016; PubMed: 27791178; DOI: 10.1073/pnas.1615316113

実験手法

X-RAY DIFFRACTION (2 Å)