5T68
Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine
Summary for 5T68
Entry DOI | 10.2210/pdb5t68/pdb |
Descriptor | Tyrosine-protein kinase SYK, N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine (3 entities in total) |
Functional Keywords | spleen tyrosine kinase syk catalytic domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 2 |
Total formula weight | 68408.71 |
Authors | Argiriadi, M.A.,Hoemann, M.,Wilson, N.,Banach, D.,Burchat, A.,Calderwood, D.,Clapham, B.,Cox, P.,Duignan, D.B.,Konopacki, D.,Somal, G.,Vasudevan, A. (deposition date: 2016-09-01, release date: 2016-10-26, Last modification date: 2023-10-04) |
Primary citation | Hoemann, M.,Wilson, N.,Argiriadi, M.,Banach, D.,Burchat, A.,Calderwood, D.,Clapham, B.,Cox, P.,Duignan, D.B.,Konopacki, D.,Somal, G.,Vasudevan, A. Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg. Med. Chem. Lett., 26:5562-5567, 2016 Cited by PubMed: 27789138DOI: 10.1016/j.bmcl.2016.09.077 PDB entries with the same primary citation |
Experimental method |
Structure validation
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