5T4Z

STRUCTURE OF THE ANTI-HIV ANTIBODY DH501 THAT BINDS GP120 V3 GLYCAN AND THE BASE OF V3 WITH FREE MAN9 GLYCAN

Summary for 5T4Z

• Entry DOI: 10.2210/pdb5t4z/pdb
• Related: 5IIE
• Descriptor: antibody DH501 Fab heavy chain, antibody DH501 Fab light chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose, ... (5 entities in total)
• Functional Keywords: hiv-1 antibody gp120, immune system
• Biological source: Macaca mulatta (Rhesus monkey); More
• Total number of polymer chains: 4
• Total formula weight: 95582.76

Authors

Nicely, N.I.,Haynes, B.F. (deposition date: 2016-08-30, release date: 2017-03-08, Last modification date: 2023-10-04)

• Primary citation: Saunders, K.O.,Nicely, N.I.,Wiehe, K.,Bonsignori, M.,Meyerhoff, R.R.,Parks, R.,Walkowicz, W.E.,Aussedat, B.,Wu, N.R.,Cai, F.,Vohra, Y.,Park, P.K.,Eaton, A.,Go, E.P.,Sutherland, L.L.,Scearce, R.M.,Barouch, D.H.,Zhang, R.,Von Holle, T.,Overman, R.G.,Anasti, K.,Sanders, R.W.,Moody, M.A.,Kepler, T.B.,Korber, B.,Desaire, H.,Santra, S.,Letvin, N.L.,Nabel, G.J.,Montefiori, D.C.,Tomaras, G.D.,Liao, H.X.,Alam, S.M.,Danishefsky, S.J.,Haynes, B.F.; Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.; Cell Rep, 18:2175-2188, 2017; PubMed: 28249163; DOI: 10.1016/j.celrep.2017.02.003

Experimental method

X-RAY DIFFRACTION (1.991 Å)