5T3Q
Crystal structure of the c-Met kinase domain in complex with a pyrazolone inhibitor
Summary for 5T3Q
Entry DOI | 10.2210/pdb5t3q/pdb |
Related | 3U6I |
Descriptor | Hepatocyte growth factor receptor, N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | phosphotransferase, cancer, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35772.30 |
Authors | Bellon, S.F.,Whittington, D.A.,Long, A.M. (deposition date: 2016-08-26, release date: 2016-09-21, Last modification date: 2024-04-03) |
Primary citation | Boezio, A.A.,Peterson, E.A.,Harmange, J.-C. Discovery of AMG337: Using structure guided scaffold hydridization to optimize physicochemical properties and target coverage of a MET kinase inhibitor to be published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report