5T3Q

Crystal structure of the c-Met kinase domain in complex with a pyrazolone inhibitor

Summary for 5T3Q

• Entry DOI: 10.2210/pdb5t3q/pdb
• Related: 3U6I
• Descriptor: Hepatocyte growth factor receptor, N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (3 entities in total)
• Functional Keywords: phosphotransferase, cancer, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 1
• Total formula weight: 35772.30

Authors

Bellon, S.F.,Whittington, D.A.,Long, A.M. (deposition date: 2016-08-26, release date: 2016-09-21, Last modification date: 2024-04-03)

• Primary citation: Boezio, A.A.,Peterson, E.A.,Harmange, J.-C.; Discovery of AMG337: Using structure guided scaffold hydridization to optimize physicochemical properties and target coverage of a MET kinase inhibitor; to be published,

Experimental method

X-RAY DIFFRACTION (2 Å)