5T3Q

Crystal structure of the c-Met kinase domain in complex with a pyrazolone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor receptor	polymer	309	35215.7	1	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (Human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
2	A	N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide	non-polymer		556.6	1	Chemie (75H)
3		water	water		18.0	218	Chemie (HOH)

Sequence modifications

A: 1048 - 1350 (UniProt: P08581)

PDB	External Database	Details
His 1351	-	expression tag
His 1352	-	expression tag
His 1353	-	expression tag
His 1354	-	expression tag
His 1355	-	expression tag
His 1356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35215.7
Non-Polymers*	Number of molecules	1
	Total formula weight	556.6
All*	Total formula weight	35772.3

*Water molecules are not included.