5T2Y

Crystal Structure of C. jejuni PglD in complex with 5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid

Summary for 5T2Y

Entry DOI	10.2210/pdb5t2y/pdb
Related	3BSS 3BSY
Descriptor	UDP-N-acetylbacillosamine N-acetyltransferase, 5-methyl-4-(methylamino)-2-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxylic acid, GLYCEROL, ... (5 entities in total)
Functional Keywords	campylobacter jejuni bacterial acetyltransferase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Total number of polymer chains	2
Total formula weight	43867.26
Authors	De Schutter, J.W.,Imperiali, B. (deposition date: 2016-08-24, release date: 2017-02-22, Last modification date: 2024-03-06)
Primary citation	De Schutter, J.W.,Morrison, J.P.,Morrison, M.J.,Ciulli, A.,Imperiali, B. Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni. J. Med. Chem., 60:2099-2118, 2017 Cited by PubMed: 28182413 DOI: 10.1021/acs.jmedchem.6b01869 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation