5T0P

c-Src kinase domain in complex with Rao-IV-151

Summary for 5T0P

• Entry DOI: 10.2210/pdb5t0p/pdb
• Related: 5SWH
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, (2E)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)prop-2-enamide (3 entities in total)
• Functional Keywords: active conformation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 66339.13

Authors

Dieter, E.M.,Merritt, E.A.,Maly, D.J. (deposition date: 2016-08-16, release date: 2017-08-23, Last modification date: 2023-10-04)

• Primary citation: Register, A.C.,Maly, D.J.; A chemical genetic method for conformation-selective kinase inhibition; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)