5T0P
c-Src kinase domain in complex with Rao-IV-151
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32730.7 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (Chicken) | Proto-oncogene c-Src,pp60c-src,p60-Src |
| 2 | C, D (A, B) | (2E)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)prop-2-enamide | non-polymer | 438.9 | 2 | Chemie (73A) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | expression tag |
| His 249 | - | expression tag |
| Met 250 | - | expression tag |
| Cys 313 | Val 313 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65461.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 877.8 | |
| All* | Total formula weight | 66339.1 |
