5SZ6

Carbonic anhydrase IX-mimic in complex with 4-(3-formylphenyl)-benzenesulfonamide

Summary for 5SZ6

Entry DOI	10.2210/pdb5sz6/pdb
Related	5SZ0 5SZ1 5SZ2 5SZ3 5SZ4 5SZ5 5SZ7
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-(3-formylphenyl)-benzenesulfonamide, ... (6 entities in total)
Functional Keywords	sulfonamide, inhibitor, zinc-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29419.53
Authors	Bhatt, A.,Mahon, B.P.,Cornelio, B.,McKenna, R. (deposition date: 2016-08-12, release date: 2016-12-28, Last modification date: 2023-10-04)
Primary citation	Bhatt, A.,Mahon, B.P.,Cruzeiro, V.W.,Cornelio, B.,Laronze-Cochard, M.,Ceruso, M.,Sapi, J.,Rance, G.A.,Khlobystov, A.N.,Fontana, A.,Roitberg, A.,Supuran, C.T.,McKenna, R. Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity. Chembiochem, 18:213-222, 2017 Cited by PubMed: 27860128 DOI: 10.1002/cbic.201600513 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation