5SZ3

Carbonic anhydrase II in complex with 4-(3-quinolinyl)-benzenesulfonamide

Summary for 5SZ3

• Entry DOI: 10.2210/pdb5sz3/pdb
• Related: 5SZ0 5SZ1 5SZ2 5SZ4 5SZ5 5SZ6 5SZ7
• Descriptor: Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: sulfonamide, inhibitor, zinc-binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 29673.05

Authors

Bhatt, A.,Mahon, B.P.,Cornelio, B.,McKenna, R. (deposition date: 2016-08-12, release date: 2016-12-21, Last modification date: 2023-10-04)

• Primary citation: Bhatt, A.,Mahon, B.P.,Cruzeiro, V.W.,Cornelio, B.,Laronze-Cochard, M.,Ceruso, M.,Sapi, J.,Rance, G.A.,Khlobystov, A.N.,Fontana, A.,Roitberg, A.,Supuran, C.T.,McKenna, R.; Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity.; Chembiochem, 18:213-222, 2017; PubMed: 27860128; DOI: 10.1002/cbic.201600513

Experimental method

X-RAY DIFFRACTION (1.689 Å)