5SYE

Near-atomic resolution cryo-EM reconstruction of doubly bound Taxol- and peloruside-stabilized microtubule

Summary for 5SYE

• Entry DOI: 10.2210/pdb5sye/pdb
• Related: 5SYC 5SYF 5SYG
• EMDB information: 8320 8321 8322 8323
• Descriptor: Tubulin alpha chain, Tubulin beta chain, GUANOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: taxol, peloruside, microtubule, structural protein
• Biological source: Sus scrofa (Pig); More
• Total number of polymer chains: 2
• Total formula weight: 98898.16

Authors

Kellogg, E.H.,Nogales, E. (deposition date: 2016-08-10, release date: 2017-02-01, Last modification date: 2024-03-06)

• Primary citation: Kellogg, E.H.,Hejab, N.M.,Howes, S.,Northcote, P.,Miller, J.H.,Diaz, J.F.,Downing, K.H.,Nogales, E.; Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.; J. Mol. Biol., 429:633-646, 2017; PubMed: 28104363; DOI: 10.1016/j.jmb.2017.01.001

Experimental method

ELECTRON MICROSCOPY (3.5 Å)