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5SWQ

Crystal Structure of HLA-A*0201 in complex with NA231, an influenza epitope

Summary for 5SWQ
Entry DOI10.2210/pdb5swq/pdb
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NA231 influenza epitope, ... (4 entities in total)
Functional Keywordshla-a*02:01, cross-reactivity, heterologous immunity, tcr, t cell, immune system
Biological sourceHomo sapiens (Human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted . Note=(Microbial infection) In the presence of M: P61769
Total number of polymer chains3
Total formula weight44656.60
Authors
Josephs, T.M.,Rossjohn, J.,Gras, S. (deposition date: 2016-08-08, release date: 2016-10-05, Last modification date: 2023-10-04)
Primary citationGrant, E.J.,Josephs, T.M.,Valkenburg, S.A.,Wooldridge, L.,Hellard, M.,Rossjohn, J.,Bharadwaj, M.,Kedzierska, K.,Gras, S.
Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alpha beta T Cell Receptor Signatures.
J.Biol.Chem., 291:24335-24351, 2016
Cited by
PubMed: 27645996
DOI: 10.1074/jbc.M116.753988
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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