5SWK

Crystal structure of p53 epitope-scaffold based on a inhibitor of cysteine proteases in complex with human MDM2

5SWK の概要

• エントリーDOI: 10.2210/pdb5swk/pdb
• 分子名称: E3 ubiquitin-protein ligase Mdm2, De novo protein based on the inhibitor Amoebiasin-1, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: peptidomimetics, biosensor, scaffold, designed, de novo protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 59083.99

構造登録者

Jimenez-Sandoval, P.,Brieba, L.G. (登録日: 2016-08-08, 公開日: 2017-10-18, 最終更新日: 2023-10-04)

• 主引用文献: Jimenez-Sandoval, P.,Madrigal-Carrillo, E.A.,Santamaria-Suarez, H.A.,Maturana, D.,Renteria-Gonzalez, I.,Benitez-Cardoza, C.G.,Torres-Larios, A.,Brieba, L.G.; Mimicking a p53-MDM2 interaction based on a stable immunoglobulin-like domain scaffold.; Proteins, 86:802-812, 2018; PubMed: 29696695; DOI: 10.1002/prot.25519

実験手法

X-RAY DIFFRACTION (1.923 Å)