5SVF

IDH1 R132H in complex with IDH125

Summary for 5SVF

Entry DOI	10.2210/pdb5svf/pdb
Related	5SUN 5SVN 5SVO
Descriptor	Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4S)-3-(2-{[(1S)-1-phenylethyl]amino}pyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one, ... (5 entities in total)
Functional Keywords	isocitrate dehydrogenase, rossmann fold, nadph, inhibitor, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : O75874
Total number of polymer chains	4
Total formula weight	192693.22
Authors	Xie, X.,Kulathila, R. (deposition date: 2016-08-05, release date: 2017-02-08, Last modification date: 2024-03-06)
Primary citation	Xie, X.,Baird, D.,Bowen, K.,Capka, V.,Chen, J.,Chenail, G.,Cho, Y.,Dooley, J.,Farsidjani, A.,Fortin, P.,Kohls, D.,Kulathila, R.,Lin, F.,McKay, D.,Rodrigues, L.,Sage, D.,Toure, B.B.,van der Plas, S.,Wright, K.,Xu, M.,Yin, H.,Levell, J.,Pagliarini, R.A. Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. Structure, 25:506-513, 2017 Cited by PubMed: 28132785 DOI: 10.1016/j.str.2016.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation