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5SKD

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C1=CN(N=C(C1=O)c2ccnn2c3cc(ccc3F)F)c4cc(ccc4)OC(F)(F)F, micromolar IC50=0.047063

Summary for 5SKD
Entry DOI10.2210/pdb5skd/pdb
Group depositionTo be published (G_1002229)
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordsphosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total formula weight160968.30
Authors
Joseph, C.,Benz, J.,Flohr, A.,Rogers-Evans, M.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-10-16)
Primary citationFlohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G.
Crystal Structure of a human phosphodiesterase 10 complex
To be published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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PDB entries from 2024-11-13

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