5SI0

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n4c(n1c(nc(n1)CCc2nn(c(n2)N3CCCC3)C)cc4C)CCc5nn(c(n5)N6CCCC6)C, micromolar IC50=0.047938

Summary for 5SI0

• Entry DOI: 10.2210/pdb5si0/pdb
• Group deposition: To be published (G_1002229)
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 159974.10

Authors

Joseph, C.,Benz, J.,Flohr, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-10-16)

• Primary citation: Flohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a human phosphodiesterase 10 complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.27 Å)