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5QA7

OXA-48 IN COMPLEX WITH COMPOUND 4b

Summary for 5QA7
Entry DOI10.2210/pdb5qa7/pdb
Group depositionA focused fragment library targeting the antibiotic resistance enzyme - oxacillinase-48: synthesis, structural evaluation and inhibitor design (G_1002027)
DescriptorBeta-lactamase, 3-(3-hydroxyphenyl)benzoic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordsoxacillinase, inhibitor, complex, oxa, antibiotic resistance, beta-lactamase, fragment, hydrolase
Biological sourceKlebsiella pneumoniae
Total number of polymer chains4
Total formula weight114394.19
Authors
Lund, B.A.,Leiros, H.K.S. (deposition date: 2017-07-11, release date: 2018-01-10, Last modification date: 2023-11-15)
Primary citationAkhter, S.,Lund, B.A.,Ismael, A.,Langer, M.,Isaksson, J.,Christopeit, T.,Leiros, H.S.,Bayer, A.
A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.
Eur J Med Chem, 145:634-648, 2018
Cited by
PubMed: 29348071
DOI: 10.1016/j.ejmech.2017.12.085
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.82 Å)
Structure validation

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