5QA7

OXA-48 IN COMPLEX WITH COMPOUND 4b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue IQQ A 301

Chain	Residue
A	ILE102
A	HOH710
A	TYR117
A	THR209
A	TYR211
A	SER244
A	ARG250
A	HOH412
A	HOH592
A	HOH700

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	SER40
A	ASP240
A	MET241
A	PRO242
A	HOH433
A	HOH475

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 303

Chain	Residue
A	HIS38
A	GLU256

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 304

Chain	Residue
A	LEU81
A	SER184
A	ARG186
A	SER187
A	HOH496

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 305

Chain	Residue
A	ARG206
C	ARG206
C	HOH630

---

site_id	AC6
Number of Residues	7
Details	binding site for residue IQQ B 301

Chain	Residue
B	ILE102
B	TYR117
B	THR209
B	SER244
B	ARG250
B	HOH403
B	HOH684

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO B 302

Chain	Residue
B	LYS39
B	SER40
B	ASP240
B	MET241
B	PRO242
B	HOH444
B	HOH462

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO B 303

Chain	Residue
B	SER184
B	ARG186
B	SER187
B	HOH470
B	HOH516

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CL B 304

Chain	Residue
B	ARG206

---

site_id	AD1
Number of Residues	7
Details	binding site for residue IQQ C 301

Chain	Residue
C	ILE102
C	TYR117
C	THR209
C	SER244
C	ARG250
C	HOH401
C	HOH417

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO C 302

Chain	Residue
C	LEU81
C	SER184
C	ARG186
C	SER187
C	HOH462

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO C 303

Chain	Residue
C	VAL85
C	GLN91
C	GLN129
C	HOH592

---

site_id	AD4
Number of Residues	8
Details	binding site for residue IQQ D 301

Chain	Residue
D	ILE102
D	TYR117
D	TYR211
D	SER244
D	ARG250
D	HOH401
D	HOH412
D	HOH417

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO D 302

Chain	Residue
D	LEU81
D	SER184
D	ARG186
D	SER187
D	HOH444

---

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO D 303

Chain	Residue
D	THR167
D	SER171
D	ARG174

---

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL

Chain	Residue	Details
A	PRO68-LEU78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Acyl-ester intermediate => ECO:0000255|PIRSR:PIRSR602137-50, ECO:0000269|PubMed:25406838, ECO:0000269|PubMed:26731698, ECO:0000269|PubMed:31358584, ECO:0000269|PubMed:32150407, ECO:0007744|PDB:4WMC, ECO:0007744|PDB:5FAQ, ECO:0007744|PDB:5FAS, ECO:0007744|PDB:6P97, ECO:0007744|PDB:6P98, ECO:0007744|PDB:6P99, ECO:0007744|PDB:6P9C, ECO:0007744|PDB:6V1O

Chain	Residue	Details
A	SER70
B	SER70
C	SER70
D	SER70

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q8RLA6

Chain	Residue	Details
A	SER70
D	SER70
D	SER118
D	ARG250
A	SER118
A	ARG250
B	SER70
B	SER118
B	ARG250
C	SER70
C	SER118
C	ARG250

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P13661

Chain	Residue	Details
A	KCX73
B	KCX73
C	KCX73
D	KCX73

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-carboxylysine => ECO:0000255|PIRSR:PIRSR602137-50, ECO:0000269|PubMed:19477418, ECO:0000269|PubMed:25406838, ECO:0007744|PDB:3HBR, ECO:0007744|PDB:4WMC

Chain	Residue	Details
A	KCX73
B	KCX73
C	KCX73
D	KCX73

---