5OWA
Crystal structure of the human BRPF1 bromodomain in complex with BZ054
Summary for 5OWA
Entry DOI | 10.2210/pdb5owa/pdb |
Descriptor | Peregrin, ~{N}-[4-[[(3~{S},5~{R})-3,5-dimethylpiperidin-1-yl]methyl]-1,3-thiazol-2-yl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (3 entities in total) |
Functional Keywords | bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, transcription, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 55860.18 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2017-08-31, release date: 2018-06-27, Last modification date: 2024-01-17) |
Primary citation | Zhu, J.,Zhou, C.,Caflisch, A. Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155:337-352, 2018 Cited by PubMed: 29902720DOI: 10.1016/j.ejmech.2018.05.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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