5ORJ
The crystal structure of CK2alpha in complex with compound 3
Summary for 5ORJ
| Entry DOI | 10.2210/pdb5orj/pdb |
| Descriptor | Casein kinase II subunit alpha, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
| Functional Keywords | ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 85308.79 |
| Authors | Brear, P.,De Fusco, C.,Iegre, J.,Yoshida, M.,Mitchell, S.,Rossmann, M.,Carro, L.,Sore, H.,Hyvonen, M.,Spring, D. (deposition date: 2017-08-16, release date: 2018-02-28, Last modification date: 2024-01-17) |
| Primary citation | Iegre, J.,Brear, P.,De Fusco, C.,Yoshida, M.,Mitchell, S.L.,Rossmann, M.,Carro, L.,Sore, H.F.,Hyvonen, M.,Spring, D.R. Second-generation CK2 alpha inhibitors targeting the alpha D pocket. Chem Sci, 9:3041-3049, 2018 Cited by PubMed: 29732088DOI: 10.1039/c7sc05122k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
Download full validation report
