5OPM

Crystal structure of D52N/R238W cN-II mutant bound to dATP and free phosphate

Summary for 5OPM

Entry DOI	10.2210/pdb5opm/pdb
Related	5OPK 5OPL
Descriptor	Cytosolic purine 5'-nucleotidase, PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	nucleotidase, relapsed leukemia, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56355.42
Authors	Hnizda, A.,Pachl, P.,Rezacova, P. (deposition date: 2017-08-10, release date: 2018-06-13, Last modification date: 2024-01-17)
Primary citation	Hnizda, A.,Fabry, M.,Moriyama, T.,Pachl, P.,Kugler, M.,Brinsa, V.,Ascher, D.B.,Carroll, W.L.,Novak, P.,Zaliova, M.,Trka, J.,Rezacova, P.,Yang, J.J.,Veverka, V. Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32:1393-1403, 2018 Cited by PubMed: 29535428 DOI: 10.1038/s41375-018-0073-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation