5ONE
Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)
Summary for 5ONE
| Entry DOI | 10.2210/pdb5one/pdb |
| Descriptor | Aurora kinase A, 4-(propanoylamino)-~{N}-[4-[(5,8,11-trimethyl-6-oxidanylidene-pyrimido[4,5-b][1,4]benzodiazepin-2-yl)amino]phenyl]benzamide (3 entities in total) |
| Functional Keywords | aurora kinase, kinase, inhibitor complex, cell cycle, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
| Total number of polymer chains | 1 |
| Total formula weight | 33484.38 |
| Authors | Chaikuad, A.,Ferguson, F.M.,Gray, N.S.,Knapp, S. (deposition date: 2017-08-03, release date: 2017-09-06, Last modification date: 2024-01-17) |
| Primary citation | Ferguson, F.M.,Doctor, Z.M.,Chaikuad, A.,Sim, T.,Kim, N.D.,Knapp, S.,Gray, N.S. Characterization of a highly selective inhibitor of the Aurora kinases. Bioorg. Med. Chem. Lett., 27:4405-4408, 2017 Cited by PubMed: 28818446DOI: 10.1016/j.bmcl.2017.08.016 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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